ea0020p440 | Obesity and Metabolism | ECE2009
Romanatto Talita
, Roman Erika A
, Denis Rapahel G
, Arruda Ana Paula
, Milanski Marciane
, Degasperi Giovanna
, Solon Carina
, Velloso Licio A
Abstract: Obesity results from an imbalance between caloric intake and energy expenditure. Specialized neurons of the hypothalamus coordinately control the integration between feeding and thermogenesis and a defective regulation of these parameters contribute to the progressive accumulation of body fat. Recent studies have revealed that at least part of hypothalamic dysfunction contributing to the development of obesity results from the activation of a local inflammatory respo...